Action Potential Parameters Affecting Excitation-Contraction Coupling
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منابع مشابه
Action Potential Parameters Affecting Excitation-Contraction Coupling
In quantifying type B potentiation effects, given earlier merely qualitatively, it is found that Zn(2+), 1-50 microM, causes increases in action potential duration, twitch tension, and twitch contraction period time, which are all directly proportional to the log of the concentration. Hence, the duration of the action potential, i.e. the magnitude of its mechanically effective period, is a caus...
متن کاملAltered Excitation-Contraction Coupling
Heart Failure After Myocardial Infarction : Altered Excitation-Contraction Coupling Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2001 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/hc3201.092285 2001;104:688-693 Circulation. http://circ.ahajournals.org/content/10...
متن کاملExcitation-Contraction Coupling
Previous studies have demonstrated that the ability of (.adrenergic receptor (.BAR) stimulation to increase cardiac contractility declines with aging. In the present study, the control mechanisms of excitation-contraction (EC) coupling, including calcium current (Ice), cytosolic Ca2" (Ca?') transient and contraction in response to BAR stimulation were investigated in ventricular myocytes isolat...
متن کاملCalmodulin and Excitation-Contraction Coupling.
Excitation-contraction coupling in cardiac and skeletal muscle involves the transverse-tubule voltage-dependent Ca(2+) channel and the sarcoplasmic reticulum Ca(2+) release channel. Both of these ion channels bind and are modulated by calmodulin in both its Ca(2+)-bound and Ca(2+)-free forms. Calmodulin is, therefore, potentially an important regulator of excitation-contraction coupling. Its pr...
متن کاملExcitation-Contraction Coupling and Digitalis
T HE PRIMARY task of heart muscle is to develop force and shorten at regular intervals. The action potential is the initial step in triggering contraction of the heart, and it may also be an important regulator of contraction strength. The process that links this membrane electrical event to the contraction is given the broad name of excitation-contraction coupling. The more we have increased o...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1972
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.59.4.421